Identification of a Basement Membrane Zone Antigen Reactive with Circulating IgA Antibody in Ocular Cicatricial Pemphigoid
نویسندگان
چکیده
منابع مشابه
Ocular Cicatricial Pemphigoid
CC (6/20/96): Red, itchy eyes, whitish discharge x 6 weeks HPI: A 74 year old retired policeman noticed red, itchy eyes associated with whitish discharge that worsened over the past six weeks. Two weeks later, the patient consulted his ophthalmologist, who treated him antibiotic eye drops without a favorable response. The patient did not respond to the antibiotic and states he was biopsied. He ...
متن کاملIdentification of ocular cicatricial pemphigoid antibody binding site(s) in human beta4 integrin.
PURPOSE To identify specific site(s) on human ss4 molecule to which sera from ocular cicatricial pemphigoid (OCP) patients bind and to determine its role in the process of blister formation. METHODS Clone the fragments representing the extracellular and intracellular domain of ss4 molecule from normal human conjunctival mRNA into an expression vector; map the region to which sera from OCP pat...
متن کاملProgression of disease in ocular cicatricial pemphigoid.
BACKGROUND Ocular cicatricial pemphigoid (OCP) is a sight threatening autoimmune disease that can lead to severe conjunctival cicatrisation and keratopathy. It has a variable course and little is known about the factors that determine disease progression. This study analysed the factors that have prognostic significance regarding disease outcome, progression, and keratopathy. METHODS Sixty si...
متن کاملCataract surgery in ocular cicatricial pemphigoid.
The authors report the results of their experience with cataract surgery in 20 patients (26 eyes) with biopsy-proven cicatricial pemphigoid. All patients were on systemic immunosuppression at the time of surgery (dapsone, azathioprine, cyclophosphamide, or combinations) and were treated with perioperative oral corticosteroids. Patients were evaluated pre- and postoperatively for conjunctival in...
متن کاملOcular involvement in anti-epiligrin cicatricial pemphigoid.
PURPOSE To report an anti-epiligrin cicatricial pemphigoid (AECP) patient with severe ocular involvement and to provide a practical approach to distinguishing AECP patients from those with other subepidermal blistering diseases. METHODS Techniques included direct and indirect immunofluorescence microscopy, Western blot and immunoprecipitation studies, as well as interdisciplinary examinations...
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ژورنال
عنوان ژورنال: Journal of Investigative Dermatology
سال: 1993
ISSN: 0022-202X
DOI: 10.1111/1523-1747.ep12366078